Diabetes

Vol. 57 ; part 7

Perspectives in Diabetes:

Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes
Reza Abdi, Paolo Fiorina, Chaker N. Adra, Mark Atkinson, and Mohamed H. Sayegh

Neurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control
Deborah A. Cohen

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
Carsten Schmitz-Peiffer and Trevor J. Biden

Commentaries:

The Pol-e-Pill Finally Arrives
James A. Levine and Ronald M. Davis

Obesity: Increasing Awareness of Novel Environmental Factors
Kevin D. Niswender and Bettina M. Beech

Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes
Eddie A. James and William W. Kwok

New Methodologies and Databases

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains
Eric D. Berglund, Candice Y. Li, Greg Poffenberger, Julio E. Ayala, Patrick T. Fueger, Shannon E. Willis, Marybeth M. Jewell, Alvin C. Powers, and David H. Wasserman

Metabolism

Plasma C5 Glucose–to–2H2O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis During Hyperinsulinemic-Euglycemic Clamps in Either Nondiabetic or Diabetic Humans
Rita Basu, Visvanathan Chandramouli, Betty Dicke, Bernard R. Landau, and Robert A. Rizza

Signal Transduction

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
Zhong Q. Wang, William T. Cefalu, Xian H. Zhang, Yongmei Yu, Jianhua Qin, Leslie Son, Pamela M. Rogers, Nazar Mashtalir, Justin R. Bordelon, Jianping Ye, and Nikhil V. Dhurandhar

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
Jen-Ying Deng, Po-Shiuan Hsieh, Jiung-Pang Huang, Long-Sheng Lu, and Li-Man Hung

Obesity Studies

Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism
Liping Qiao, Chenhui Zou, Deneys R. van der Westhuyzen, and Jianhua Shao

Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects: Effect of β-Adrenergic Stimulation
Johan W.E. Jocken, Carsten Roepstorff, Gijs H. Goossens, Paula van der Baan, Marleen van Baak, Wim H.M. Saris, Bente Kiens, and Ellen E. Blaak

Blockade of 4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity
Chloé C. Féral, Jaap G. Neels, Christiane Kummer, Marina Slepak, Jerrold M. Olefsky, and Mark H. Ginsberg

Immunology and Transplantation

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice
Matteo G. Levisetti, Danna M. Lewis, Anish Suri, and Emil R. Unanue

Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models
Chia-Jen Wang, Feng-Cheng Chou, Chi-Hong Chu, Jen-Chine Wu, Shih-Hua Lin, Deh-Ming Chang, and Huey-Kang Sytwu

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
Johan Olerud, Magnus Johansson, Jack Lawler, Nils Welsh, and Per-Ola Carlsson

Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice
George Vlad, Vivette D. D'Agati, Qing-Yin Zhang, Zhuoru Liu, Eric K. Ho, Thalachallour Mohanakumar, Mark A. Hardy, Raffaello Cortesini, and Nicole Suciu-Foca

Islet Studies

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion: A New Mechanism for Fat-Induced Impairment of β-Cell Function
Melkam Kebede, Jenny Favaloro, Jenny E. Gunton, D. Ross Laybutt, Margaret Shaw, Nicole Wong, Barbara C. Fam, Kathryn Aston-Mourney, Christian Rantzau, Anthony Zulli, Joseph Proietto, and Sofianos Andrikopoulos

MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH2-Terminal Kinase and Nuclear Factor-B Activation in Human Pancreatic Islet Cells
Dariush Mokhtari, Jason W. Myers, and Nils Welsh

Pathophysiology

Effect of Oral Amino Acids on Counterregulatory Responses and Cognitive Function During Insulin-Induced Hypoglycemia in Nondiabetic and Type 1 Diabetic People
Paolo Rossetti, Francesca Porcellati, Natalia Busciantella Ricci, Paola Candeloro, Patrizia Cioli, K. Sreekumaran Nair, Fausto Santeusanio, Geremia B. Bolli, and Carmine G. Fanelli

Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload
José Manuel Fernández-Real, José María Moreno, and Wifredo Ricart

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
Kristen M. Picha, Mark R. Cunningham, Daniel J. Drucker, Ashok Mathur, Tatiana Ort, Michael Scully, Avery Soderman, Tracy Spinka-Doms, Vedrana Stojanovic-Susulic, Beth Ann Thomas, and Karyn T. O'Neil

Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence
Maha Abdulhadi-Atwan, Jeremy D. Bushman, Sharona Tornovsky-Babaey, Avital Perry, Abdulsalam Abu-Libdeh, Benjamin Glaser, Show-Ling Shyng, and David H. Zangen

Complications

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium
Loredana G. Bucciarelli, Radha Ananthakrishnan, Yuying C. Hwang, Michiyo Kaneko, Fei Song, David R. Sell, Christopher Strauch, Vincent M. Monnier, Shi Fang Yan, Ann Marie Schmidt, and Ravichandran Ramasamy

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators
Julia V. Busik, Susanne Mohr, and Maria B. Grant

Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study: A Novel Circulating Marker for Diabetic Neuropathy
Gabriella Gruden, Graziella Bruno, Nish Chaturvedi, Davina Burt, Casper Schalkwijk, Silvia Pinach, Coen D. Stehouwer, Daniel R. Witte, John H. Fuller, Paolo Cavallo Perin, and the EURODIAB Prospective Complications Study Group

Genetics

Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study
Elliot S. Stolerman, Alisa K. Manning, Jarred B. McAteer, Josée Dupuis, Caroline S. Fox, L. Adrienne Cupples, James B. Meigs, and Jose C. Florez

Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts
Lorna W. Harries, Melissa J. Sloman, Elizabeth A.C. Sellers, Andrew T. Hattersley, and Sian Ellard

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes
Hui-Qi Qu, Struan F.A. Grant, Jonathan P. Bradfield, Cecilia Kim, Edward Frackelton, Hakon Hakonarson, and Constantin Polychronakos

Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
Amanda F. Marvelle, Leslie A. Lange, Li Qin, Linda S. Adair, and Karen L. Mohlke

Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians
Konsta Duesing, Ghazaleh Fatemifar, Guillaume Charpentier, Michel Marre, Jean Tichet, Serge Hercberg, Beverley Balkau, Philippe Froguel, and Fernando Gibson